Antipsychotic Drug Blocks Triple-Negative Breast Cancer Growth

The results of studies by a team of scientists in the U.K. and Spain suggest that the commonly used antipsychotic drug Pimozide could offer a new treatment approach to the most hard to treat form of breast cancer, and potentially for lung cancer. The research, headed by Mohamed El-Tanani, Ph.D., professor of molecular pathology and cancer therapeutics at the University of Bradford, found that Pimozide significantly reduced the size and number of human triple-negative breast cancer tumors in mice, and almost completely stopped the tumors from metastasizing to the lung.

Although previous studies have hinted that antipsychotic drugs may have some anticancer properties, the latest research, published in Oncotarget , is the first to suggest mechanisms by which the antipsychotic drug inhibits cancer. “Triple-negative breast cancer has lower survival rates and increased risk of recurrence,” comments Dr. El-Tanani. It is the only type of breast cancer for which only ...