Fully Automomous DNA Nanorobots Target and Starve Tumors in Mice

A team of scientists in the U.S. and China has created programmable DNA origami nanorobots that can seek out and shrink tumors by blocking their blood supply. Tests in mice carrying breast, melanoma, ovarian, and lung tumors showed how the DNA nanorobots homed in on cancer-feeding blood vessels and induced the formation of clots, which effectively shut off the tumors' lifeline of oxygen and nutrients. The results included stunted tumor growth, shrinkage of existing tumors and metastasis, and inhibition of metastases. Animals treated using nanorobot injections survived for longer, and in some cases demonstrated complete tumor regression. Critically, the nanorobots were found to be safe and didn’t trigger immune responses when tested in normal mice and pigs.

"We have developed the first fully autonomous, DNA robotic system for a very precise drug design and targeted cancer therapy," claims Hao Yan, Ph.D., director of the Arizona State University (ASU) ...