Huntington’s and Rheumatoid Arthritis Origins Epigenetically Linked

Multifactorial diseases are notoriously difficult to treat, as their molecular roots are convoluted and enigmatic. Yet in the genomic age, new scientific endeavors are beginning to reveal some interesting connections between seemingly unrelated disorders. For instance, a new study from investigators at the University of California San Diego School of Medicine and the Icahn School of Medicine at Mount Sinai provides insight on the epigenetic landscape for rheumatoid arthritis (RA) and Huntington’s disease. Findings from the new study were published recently in Nature Communications , in an article entitled “ Comprehensive Epigenetic Landscape of Rheumatoid Arthritis Fibroblast-Like Synoviocytes .”

In unveiling RA's epigenome—the proteins and molecules that decorate DNA and help turn genes on and off—scientists made a surprising discovery: an overlap between the causes of RA and Huntington's disease. The researchers noted that the unexpected connection between RA and Huntington's disease opens the possibility of new therapeutic ...