Researchers Link 110 Genes with Breast Cancer

Scientists at The Institute of Cancer Research, London (U.K.) have used a high-throughput genetic analysis technique known as Capture Hi-C (CHi-C) to link 110 genes with an increased risk of breast cancer. The high-resolution technique can identify how regulatory genetic elements physically interact with distant protein-coding genes, even when separated by megabases (Mb) of DNA. The ICR researchers used CHi-C to analyze 63 genome regions that previous genome-wide association studies (GWAS) had linked with breast cancer. Among the 110 genes identified using CHi-C, 32 were subsequently linked with breast cancer survival.

"Our study took the high-level maps of breast cancer risk regions and used them to pull out specific genes that seem to be associated with the disease,” explains Olivia Fletcher, Ph.D., team leader in functional genetic epidemiology at The Institute of Cancer Research, and co-corresponding author of the team’s published paper in Nature Communications . "We studied ...