Single-Cell Genetic Atlas of Breast Development Reveals New Cancer Targets

Scientists have recognized the relationship between normal organ development and cancer for more than 100 years. More recently, researches have begun to emphasize that the heterogeneous nature of most cancers largely contributes towards their clinical response. Now, a team of investigators at Huntsman Cancer Institute (HCI) at the University of Utah (U of U) and the Salk Institute for Biological Studies, have created the first single cell resolution atlas of genes that control the formation of breast tissue. The atlas provides a comprehensive molecular map that the researchers are optimistic will be used to help understand how breast cancers form and to pinpoint new ways to prevent, diagnose, and treat the disease.

Findings from the new study were published recently in Cell Reports through an article titled “ Single-Cell Transcriptomes Distinguish Stem Cell State Changes and Lineage Specification Programs in Early Mammary Gland Development .”

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