Tracking Molecular Development of Sepsis May Lead to Improved Therapies

Scientists at the University of California-Santa Barbara, Sanford Prebys Medical Discovery Institute (SBP), and UC-San Diego say they have developed a method for tracking the development of sepsis on a molecular basis. They believe their discoveries could, in turn, lead to more advanced therapies for sepsis that reduce its mortality, minimize the life-long effects for survivors or even prevent the cascade of life-threatening effects before it begins, while reducing the billions of dollars spent every year to treat the condition.

Their study (“ Accelerated Aging and Clearance of Host Anti-inflammatory by Discrete Pathogens Fuels Sepsis ”) is published in Cell Host & Microbe .

“Sepsis is a life-threatening inflammatory syndrome accompanying a bloodstream infection. Frequently secondary to pathogenic bacterial infections, sepsis remains difficult to treat as a singular disease mechanism. We compared the pathogenesis of murine sepsis experimentally elicited by five bacterial pathogens and report similarities among host ...